The New York Giants (1-1) will do their best to defy oddsmakers when they hit the field against the San Francisco 49ers (2-0) on Thursday, September 21, 2023 as a 10.5-point underdog. This contest has a listed total of 44 points.

Here's a look at the betting insights and trends for the 49ers as they ready for this matchup against the Giants. The betting insights and trends for the Giants can be seen below before you wager on their matchup against 49ers.

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49ers vs. Giants Odds, Spread, Over/Under

Here's a look at the odds, spread and over/under for this matchup at multiple sportsbooks.

Favorite Total San Francisco Moneyline New York Moneyline
BetMGM 49ers (-10.5) 44 -600 +425 Bet on this game with BetMGM
FanDuel 49ers (-10.5) 43.5 -560 +420 Bet on this game with FanDuel

Other Week 3 Odds

San Francisco vs. New York Game Info

  • When: Thursday, September 21, 2023 at 8:15 PM ET
  • Where: Levi's Stadium in Santa Clara, California
  • TV Info: Amazon Prime Video
  • Live Stream: Watch this game on Fubo!

49ers vs. Giants Betting Insights

  • San Francisco beat the spread 11 times in 17 games last year.
  • The 49ers went unbeaten ATS (1-0) as a 10.5-point favorite or greater last year.
  • San Francisco had nine of its 17 games go over the point total last year.
  • New York posted a 13-4-0 record against the spread last year.
  • The Giants were an underdog by 10.5 points or more once last year, and covered the spread.
  • In 17 New York games last season, seven of them went over the total.

49ers Player Props

Name Pass Yds Pass TDs Rush Yds Rush TDs Rec Yds Rec TDs
George Kittle - - - - 42.5 (-118) -
Christian McCaffrey - - 78.5 (-115) - 30.5 (-111) -
Brock Purdy 228.5 (-115) - 7.5 (-115) - - -
Deebo Samuel - - 14.5 (-115) - 53.5 (-111) -

Payouts above are for the "over" bet.

Giants Player Props

Name Pass Yds Pass TDs Rush Yds Rush TDs Rec Yds Rec TDs
Darren Waller - - - - 45.5 (-115) -
Matt Breida - - 31.5 (-118) - 12.5 (-118) -
Parris Campbell - - - - 28.5 (-111) -
Daniel Jones 215.5 (-115) 1.5 (+170) - - - -
Darius Slayton - - - - 34.5 (-115) -
Isaiah Hodgins - - - - 31.5 (-118) -

Payouts above are for the "over" bet.

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