Gene mutation helps predict lung cancer survival in nonsmokers - KFDA - NewsChannel 10 / Amarillo News, Weather, Sports

Gene mutation may help predict lung cancer survival in nonsmokers

Updated: Sep 12, 2013 01:28 PM
© Stockbyte / Thinkstock © Stockbyte / Thinkstock

THURSDAY, Sept. 12 (HealthDay News) -- Researchers say they've identified a gene mutation that's associated with a higher risk of lung cancer in women who do not smoke, but a better chance of survival in female and male lung cancer patients.

The mutation, which occurs in a gene that protects cells from oxidative stress, is found four times more often in women than in men, according to the study published Sept. 11 in the journal PLoS One.

The researchers analyzed the DNA of lung cancer patients in Japan and found that nonsmoking women with two copies of the -617A mutation in the NFR2 gene had a much higher incidence of lung cancer than nonsmoking men.

The investigators also found that both female and male lung cancer patients with this mutation had better survival rates than other patients.

This is the first study to provide clinical evidence that this mutation is associated with lung cancer patient survival, said researcher Dr. Toshihisa Ishikawa and colleagues at the RIKEN Center for Life Science Technologies in Japan.

The study strongly suggests that the presence of this mutation "is a good prognostic biomarker for the assessment of the overall survival chances of patients with adenocarcinoma, as well as a practical tool for personalized cancer therapy," Ishikawa said in a RIKEN news release.

Although the study found an association between the gene mutation and lung cancer survival, it did not prove a cause-and-effect relationship.

Lung cancer is the leading cause of cancer-related deaths in many industrialized countries, according to background information in the news release. Smoking is the main cause of lung cancer, but 10 percent to 15 percent of cases occur in nonsmokers.

More information

The U.S. National Cancer Institute has more about lung cancer.

Copyright © 2013 HealthDay. All rights reserved.

  • Health WatchMore>>

  • House approves VA health care overhaul

    House approves VA health care overhaul

    Wednesday, July 30 2014 9:12 PM EDT2014-07-31 01:12:40 GMT
    With a new Veterans Affairs secretary in place and an August recess looming, Congress is moving quickly to approve a compromise bill to refurbish the VA and improve veterans' health care.
    The House overwhelmingly approved a landmark bill Wednesday to help veterans avoid long waits for health care that have plagued the Veterans Affairs Department for years.
  • $1,000 Sovaldi now hepatitis treatment of choice

    $1,000 Sovaldi now hepatitis treatment of choice

    Wednesday, July 30 2014 8:58 PM EDT2014-07-31 00:58:45 GMT
    A $1,000-per-pill drug that insurers are reluctant to pay for has quickly become the treatment of choice for a liver-wasting viral disease that affects more than 3 million Americans.
    The price is sky-high, but so is demand. A new $1,000-per-pill drug has become the treatment of choice for Americans with hepatitis C, a liver-wasting disease that affects more than 3 million.
  • Deportations halted at New Mexico processing center

    Deportations halted at New Mexico processing center

    Deportations halted at New Mexico processing center

    Artesia, NM - Officials at an immigration processing center in new mexico announced they will be halting all deportations for the time being.
    Artesia, NM - Officials at an immigration processing center in new mexico announced they will be halting all deportations for the time being.
*DISCLAIMER*: The information contained in or provided through this site section is intended for general consumer understanding and education only and is not intended to be and is not a substitute for professional advice. Use of this site section and any information contained on or provided through this site section is at your own risk and any information contained on or provided through this site section is provided on an "as is" basis without any representations or warranties.